Scientific Literature | Periodontology

This list revised March 15, 2009. If you wish, you may download a PDF document containing this information.

  • 1. Bartold PM, Raben A. Growth factor modulation of fibroblasts in simulated wound healing. J Periodontal Res 1996 Apr; 31(3): 205-16.
  • 2. Bartold PM. Platelet-derived growth factor stimulates hyaluronate but not proteoglycan synthesis by human gingival fibroblasts in vitro. J Dent Res. 1993 Nov; 72(11): 1473-80.
  • 3. Bateman J, Intini G, Margarone J, Goodloe S, Bush P, Lynch S, Dziak R. Platelet-Derived Growth Factor Enhancement of Two Alloplastic Bone Matrices. J Periodontol 2005;76:1833-1841.
  • 4. Becker W, Lynch SE, Lekholm U, Becker BE, Caffesse R, Donath K, Sanchez R. A comparison of ePTFE membranes alone or in combination with platelet-derived growth factors and insulin-like growth factor-I or demineralized freeze-dried bone in promoting bone formation around immediate extraction socket implants. J Periodontol. 1992 Nov; 63(11): 929-40.
  • 5. Becerik S, Sonmez S, Sen BH, Deliloglu-Gurhan I, Evrenosoglu E. Effect of human platelet-derived growth factor-BB on attachment of periodontal ligament cells on root surfaces. Saudi Med J. 2009 Jan; 30(1): 60-6.
  • 6. Belal MH, Watanabe H, Ichinose S, Ishikawa I. A Time-dependent Effect of PDGF-BB on Adhesion and Growth of Cultured Fibroblasts to Root Surfaces. Oral Diseases. 2006 Nov; 12(6): 543-52.
  • 7. Blom S, Holmstrup P, Dabelsteen E. A comparison of the effect of epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor on rat periodontal ligament fibroblast-like cells' DNA synthesis and morphology. J Periodontol. 1994 May; 65(5): 373-8.
  • 8. Boyan LA, Bhargava G, Nishimura F, Orman R, Price R, Terranova VP. Mitogenic and chemotactic responses of human periodontal ligament cells to the different isoforms of platelet-derived growth factor. J Dent Res. 1994 Oct; 73(10): 1593-600.
  • 9. Bsoul S, Terezhalmy G, Abboud H, Woodruff K, Abboud SL. PDGF BB and bFGF stimulate DNA synthesis and upregulate CSF-1 and MCP-1 gene expression in dental follicle cells. Arch Oral Biol. 2003 Jun; 48(6): 459-65.
  • 10. Byun HY, Wang HL. Sandwich bone augmentation using recombinant human platelet- derived growth factor and beta-tricalcium phosphate alloplast: case report. Int J Periodontics Restorative Dent. 2008 Feb; 28(1): 83-7.
  • 11. Camelo M, Nevins ML, Schenk RK, Lynch SE, Nevins M. Periodontal regeneration in human Class II furcations using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with bone allograft. Int J Periodontics Restorative Dent. 2003 Jun; 23(3): 213-25.
  • 12. Cho MI, Lin WL, Genco RJ. Platelet-derived growth factor-modulated guided tissue regenerative therapy. J Periodontol. 1995 Jun; 66(6): 522-30.
  • 13. Chong CH, Carnes DL, Moritz AJ, Oates T, Ryu OH, Simmer J, Cochran DL. Human periodontal fibroblast response to enamel matrix derivative, amelogenin, and platelet- derived growth factor-BB. J Periodontol. 2006 Jul; 77(7): 1242-52.
  • 14. Chung CP, Kim DK, Park YJ, Nam Ku, Lee SJ. Biological effects of drug-loaded biodegradable membranes for guided bone regeneration. J Periodontal Res. 1997 Jan; 32(1 Pt 2): 172-5.
  • 15. Cooke JW, Sarment DP, Whitesman LA, Miller SE, Jin Q, Lynch SE, Giannobile WV. Effect of rhPDGF-BB delivery on mediators of periodontal wound repair. Tissue Eng. 2006 Jun; 12(6): 1441-50.
  • 16. Dennison DK, Vallone DR, Pinero GJ, Rittman B, Caffesse RG. Differential effect of TGF- beta 1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblasts. J Periodontol. 1994 Jul; 65(7): 641-8.
  • 17. Dereka XE, Markopoulou CE, Vrotsos IA. Role of growth factors on periodontal repair. Growth Factors. 2006 Dec;24(4):260-7.
  • 18. Fagan MC, Miller RE, Lynch SE, Kao RT. Simultaneous augmentation of hard and soft tissues for implant site preparation using recombinant human platelet-derived growth factor: a human case report. Int J Periodontics Restorative Dent. 2008 Feb;28(1):37-43
  • 19. Fuerst G, Gruber R, Tangl S, Sanroman F, Watzek G. Effects of fibrin sealant protein concentrate with and without platelet-released growth factors on bony healing of cortical mandibular defects. An experimental study in minipigs. Clin Oral Implants Res. 2004 Jun;15(3):301-7.
  • 20. Fuerst G, Gruber R, Tangl S, Sanroman F, Watzek G. Enhanced bone-to-implant contact by platelet-released growth factors in mandibular cortical bone: a histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003 Sep-Oct;18(5):685-90.
  • 21. Fujii H, Kitazawa R, Maeda S, Mizuno K, Kitazawa S. Expression of platelet-derived growth factor proteins and their receptor alpha and beta mRNAs during fracture healing in the normal mouse. Histochem Cell Biol. 1999 Aug; 112(2): 131-8.
  • 22. Gamal AY, Mailhot JM. The effect of local delivery of PDGF-BB on attachment of human periodontal ligament fibroblasts to periodontitis-affected root surfaces--in vitro. J Clin Periodontol. 2000 May; 27(5): 347-53.
  • 23. Giannobile WV, Somerman MJ. Growth and amelogenin-like factors in periodontal wound healing. A systematic review. Ann Periodontol. 2003 Dec; 8(1): 193-204.
  • 24. Giannobile WV, Lee CS, Tomala MP, Tejeda KM, Zhu Z. Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering. J Periodontol. 2001 Jun; 72(6): 815-23.
  • 25. Giannobile WV, Whitson SW, Lynch SE. Non-coordinate control of bone formation displayed by growth factor combinations with IGF-I. J Dent Res. 1997 Sep; 76(9): 1569- 78.
  • 26. Giannobile WV, Hernandez RA, Finkelman RD, Ryan S, Kiritsy CP, D'Andrea M, Lynch SE. Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor- I, individually and in combination, on periodontal regeneration in Macaca fascicularis. J Periodontal Res. 1996 Jul; 31(5): 301-12.
  • 27. Giannobile WV, Finkelman RD, Lynch SE. Comparison of canine and non-human primate animal models for periodontal regenerative therapy: results following a single administration of PDGF/IGF-I. J Periodontol. 1994 Dec; 65(12): 1158-68.
  • 28. Graves DT, Cochran DL. Biologically active mediators: platelet-derived growth factor, monocyte chemoattractant protein-1, and transforming growth factor-beta. Curr Opin Dent. 1991 Dec; 1(6): 809-15.
  • 29. Howell TH, Fiorellini JP, Paquette DW, Offenbacher S, Giannobile WV, Lynch SE. A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol. 1997 Dec; 68(12): 1186-93.
  • 30. Jiang D, Dziak R, Lynch SE, Stephan EB. Modification of an osteoconductive anorganic bovine bone mineral matrix with growth factors. J Periodontol. 1999 Aug; 70(8): 834-9.
  • 31. Lalani Z, Wong M, Brey EM, Mikos AG, Duke PJ. Spatial and temporal localization of transforming growth factor-beta1, bone morphogenetic protein-2, and platelet-derived growth factor-A in healing tooth extraction sockets in a rabbit model. Oral Maxillofac Surg. 2003 Sep;61(9):1061-72.
  • 32. Lee JY, Nam SH, Im SY, Park YJ, Lee YM, Seol YJ, Chung CP, Lee SJ. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Control Release 2002; 78: 187-97.
  • 33. Lee YM, Park YJ, Lee SJ, Ku Y, Han SB, Klokkevold PR, Chung CP. The bone regenerative effect of platelet-derived growth factor-BB delivered with a chitosan/tricalcium phosphate sponge carrier. J Periodontol. 2000 Mar; 71(3): 418-24.
  • 34. Lin Z, Sugai JV, Jin Q, Chandler LA, Giannobile WV. Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction. J Periodontal Res. 2008 Aug; 43(4): 440-9.
  • 35. Lioubavina-Hack N, Carmagnola D, Lynch SE, Karring T. Effect of Bio-Oss with or without platelet-derived growth factor on bone formation by "guided tissue regeneration": a pilot study in rats. J Clin Periodontol. 2005 Dec; 32(12): 1254-60.
  • 36. Lynch SE, Buser D, Hernandez RA, Weber HP, Stich H, Fox CH, Williams RC. Effects of the platelet-derived growth factor/insulin-like growth factor-I combination on bone regeneration around titanium dental implants. Results of a pilot study in beagle dogs. J Periodontol. 1991 Nov; 62(11): 710-6.
  • 37. Lynch SE, Nixon JC, Colvin RB, Antoniades HN. Role of platelet-derived growth factor in wound healing: synergistic effects with other growth factors. Proc Natl Acad Sci U S A. 1987 Nov; 84(21): 7696-700.
  • 38. Lynch SE, de Castilla GR, Williams RC, Kiritsy CP, Howell TH, Reddy MS, Antoniades HN. The effects of short-term application of a combination of platelet-derived and insulin- like growth factors on periodontal wound healing. J Periodontol. 1991 Jul; 62(7): 458- 67.
  • 39. Lynch SE, Trippel SB, Finkelman RD, Hernandez RA, Kiritsy CP, Antoniades HN. The combination of platelet-derived growth factor-BB and insulin-like growth factor-I stimulates bone repair in adult Yucatan miniature pigs. Wound Repair Regen. 1994 Jul; 2(3): 182-90.
  • 40. Lynch SE, Williams RC, Polson AM, Howell TH, Reddy MS, Zappa UE, Antoniades HN. A combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration. J Clin Periodontol. 1989 Sep; 16(8): 545-8.
  • 41. Lynch SE, Wisner-Lynch L, Nevins M, Nevins ML. A new era in periodontal and periimplant regeneration: use of growth-factor enhanced matrices incorporating rhPDGF. Compend Contin Educ Dent. 2006 Dec; 27(12): 672-8.
  • 42. Lynch SE, Lavin PT, Genco RJ, Beasley WG, Wisner-Lynch LA. New composite endpoints to assess efficacy in periodontal therapy clinical trials. J Periodontol. 2006 Aug; 77(8): 1314-22.
  • 43. Marcopoulou CE, Vavouraki HN, Dereka XE, Vrotsos IA. Proliferative effect of growth factors TGF-beta1, PDGF-BB and rhBMP-2 on human gingival fibroblasts and periodontal ligament cells. J Int Acad Periodontol. 2003 Jul; 5(3): 63-70.
  • 44. Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ. Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol. 1992 Jun; 63(6): 515-25.
  • 45. McAllister BS, Leeb-Lundberg F, Mellonig JT, Olson MS. The functional interaction of EGF and PDGF with bradykinin in the proliferation of human gingival fibroblasts. J Periodontol. 1995 Jun; 66(6): 429-37.
  • 46. McGuire MK, Kao RT, Nevins M, Lynch SE. rhPDGF-BB promotes healing of periodontal defects: 24-month clinical and radiographic observations. Int J Periodontics Restorative Dent. 2006 Jun; 26(3): 223-31.
  • 47. McGuire MK, Scheyer ET. Comparison of recombinant human platelet-derived growth factor-BB plus beta tricalcium phosphate and a collagen membrane to subepithelial connective tissue grafting for the treatment of recession defects: a case series. Int J Periodontics Restorative Dent. 2006 Apr; 26(2): 127-33.
  • 48. Mailhot JM, Sharawy MM, Galal M, Oldham AM, Russell CM. Porous polysulfone coated with platelet-derived growth factor-BB stimulates proliferation of human periodontal ligament fibroblasts. J Periodontol. 1996 Oct; 67(10): 981-5.
  • 49. Mott DA, Mailhot J, Cuenin MF, Sharawy M, Borke J. Enhancement of osteoblast proliferation in vitro by selective enrichment of demineralized freeze-dried bone allograft with specific growth factors. J Oral Implantol. 2002; 28(2): 57-66.
  • 50. Mumford JH, Carnes DL, Cochran DL, Oates TW. The effects of platelet-derived growth factor-BB on periodontal cells in an in vitro wound model. J Periodontol. 2001 Mar; 72(3): 331-40.
  • 51. Nevins M, Hanratty J, Lynch SE. Clinical results using recombinant human platelet- derived growth factor and mineralized freeze-dried bone allograft in periodontal defects. Int J Periodontics Restorative Dent. 2007 Oct; 27(5): 421-7.
  • 52. Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, McAllister BS, Murphy KS, McClain PK, Nevins ML, Paquette DW, Han TJ, Reddy MS, Lavin PT, Genco RJ, Lynch SE. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol. 2005 Dec; 76(12): 2205-15.
  • 53. Nevins M, Camelo M, Nevins ML, Schenk RK, Lynch SE. Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone. J Periodontol. 2003 Sep; 74(9): 1282-92.
  • 54. Nociti Júnior FH, Stefani CM, Machado MA, Sallum EA, Toledo S, Sallum AW. Histometric evaluation of bone regeneration around immediate implants partially in contact with bone: a pilot study in dogs. Implant Dent. 2000; 9(4): 321-8.
  • 55. Oates TW, Rouse CA, Cochran DL. Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J Periodontol. 1993 Feb; 64(2): 142-8.
  • 56. Oates TW, Kose KN, Xie JF, Graves DT, Collins JM, Cochran DL. Receptor binding of PDGF-AA and PDGF-BB, and the modulation of PDGF receptors by TGF-beta, in human periodontal ligament cells. J Cell Physiol. 1995 Mar; 162(3): 359-66.
  • 57. Ojima Y, Mizuno M, Kuboki Y, Komori T. In vitro effect of platelet-derived growth factor- BB on collagen synthesis and proliferation of human periodontal ligament cells. Oral Dis. 2003 May; 9(3): 144-51.
  • 58. Papadopoulos CE, Dereka XE, Vavouraki EN, Vrotsos IA. In vitro evaluation of the mitogenic effect of platelet-derived growth factor-BB on human periodontal ligament cells cultured with various bone allografts. J Periodontol. 2003 Apr; 74(4): 451-7.
  • 59. Park JB, Matsuura M, Han KY, Norderyd O, Lin WL, Genco RJ, Cho MI. Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet-derived growth factor. J Periodontol. 1995 Jun; 66(6): 462-77.
  • 60. Park YJ, Lee YM, Lee JY, Seol YJ, Chung CP, Lee SJ. Controlled release of platelet-derived growth factor-BB from chondroitin sulfate chitosan sponge for guided bone regeneration. J Control Release. 2000 Jul 3; 67(2-3): 385-94.
  • 61. Park YJ, Lee YM, Park SN, Sheen SY, Chung CP, Lee SJ. Platelet derived growth factor releasing chitosan sponge for periodontal bone regeneration. Biomaterials. 2000 Jan; 21(2): 153-9.
  • 62. Park YJ, Ku Y, Chung CP, Lee SJ. Controlled release of platelet-derived growth factor from porous poly (L-lactide) membranes for guided tissue regeneration. J Control Release. 1998 Feb 12; 51(2-3): 201-11.
  • 63. Parkar MH, Kuru L, Giouzeli M, Olsen I. Expression of growth-factor receptors in normal and regenerating human periodontal cells. Arch Oral Biol. 2001 Mar; 46(3): 275-84.
  • 64. Piché JE, Graves DT. Study of the growth factor requirements of human bone-derived cells: a comparison with human fibroblasts. Bone. 1989; 10(2): 131-8.
  • 65. Pinheiro ML, Feres-Filho EJ, Graves DT, Takiya CM, Elsas MI, Elsas PP, Luz RA. Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients. J Periodontol. 2003 Mar; 74(3): 323-8.
  • 66. Ray AK, Jones AC, Carnes DL, Cochran DL, Mellonig JT, Oates TW Jr. Platelet-derived growth factor-BB stimulated cell migration mediated through p38 signal transduction pathway in periodontal cells. J Periodontol. 2003 Sep; 74(9): 1320-8.
  • 67. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol. 2003 Dec; 8(1): 227-65.
  • 68. Ridgway HK, Mellonig JT, Cochran DL. Human histologic and clinical evaluation of recombinant human platelet-derived growth factor and beta-tricalcium phosphate for the treatment of periodontal intraosseous defects. Int J Periodontics Restorative Dent. 2008 Apr; 28(2): 171-9.
  • 69. Rosen PS. Using recombinant platelet-derived growth factor to facilitate wound healing. Compend Contin Educ Dent. 2006 Sep; 27(9): 520-5.
  • 70. Rutherford RB, Ryan ME, Kennedy JE, Tucker MM, Charette MF. Platelet-derived growth factor and dexamethasone combined with a collagen matrix induce regeneration of the periodontium in monkeys. J Clin Periodontol. 1993 Aug; 20(7): 537-44.
  • 71. Rutherford RB, Niekrash CE, Kennedy JE, Charette MF. Platelet-derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys. J Periodontal Res. 1992 Jul; 27(4 Pt 1): 285-90.
  • 72. Sant'Ana AC, Marques MM, Barroso TE, Passanezi E, de Rezende ML. Effects of TGF- beta1, PDGF-BB, and IGF-1 on the rate of proliferation and adhesion of a periodontal ligament cell lineage in vitro. J Periodontol. 2007 Oct; 78(10): 2007-17.
  • 73. Sarment DP, Cooke JW, Miller SE, Jin Q, McGuire MK, Kao RT, McClain PK, McAllister BS, Lynch SE, Giannobile WV. Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol. 2006 Feb; 33(2): 135-40.
  • 74. Simion M, Rocchietta I, Dellavia C. Three-dimensional ridge augmentation with xenograft and recombinant human platelet-derived growth factor-BB in humans: report of two cases. Int J Periodontics Restorative Dent. 2007 Apr; 27(2): 109-15.
  • 75. Simion M, Rocchietta I, Kim D, Nevins M, Fiorellini J. Vertical ridge augmentation by means of deproteinized bovine bone block and recombinant human platelet-derived growth factor-BB: a histologic study in a dog model. Int J Periodontics Restorative Dent. 2006 Oct; 26(5): 415-23.
  • 76. Stefani CM, Machado MA, Sallum EA, Sallum AW, Toledo S, Nociti FB Jr. Platelet-derived growth factor/insulin-like growth factor-I combination and bone regeneration around implants placed in the extraction sockets: a histometric study in dogs. Implant Dent. 2000; 9(2): 126-31.
  • 77. Stephan EB, Renjen R, Lynch SE, Dziak R. Platelet-derived growth factor enhancement of a mineral- collagen bone substitute. J Periodontol. 2000 Dec; 71(12): 1887-92.
  • 78. Strayhorn CL, Garrett JS, Dunn RL, Benedict JJ, Somerman MJ. Growth factors regulate expression of osteoblast-associated genes. J Periodontol. 1999 Nov; 70(11): 1345-54.
  • 79. Taba M Jr, Jin Q, Sugai JV, Giannobile WV. Current concepts in periodontal bioengineering. Orthod Craniofac Res. 2005 Nov; 8(4): 292-302.
  • 80. Trombelli L, Farina R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol. 2008 Sep; 35(8 Suppl): 117-35.
  • 81. Vavouraki HN, Dereka XE, Vrotsos IA, Markopoulou CE. Ability of a bovine bone graft, alone or enriched with PDGF-BB or rhBMP-2, to promote human periodontal ligament (PDL) cells proliferation. A preliminary study. Cell Tissue Bank. 2003; 4(1): 17-23.
  • 82. Wang HL, Pappert TD, Castelli WA, Chiego DJ Jr, Shyr Y, Smith BA. The effect of platelet- derived growth factor on the cellular response of the periodontium: an autoradiographic study on dogs. J Periodontol. 1994 May; 65(5): 429-36.
  • 83. Zaman KU, Sugaya T, Kato H. Effect of recombinant human platelet-derived growth factor-BB and bone morphogenetic protein-2 application to demineralized dentin on early periodontal ligament cell response. J Periodontal Res. 1999 Jul; 34(5): 244-50.